PASSIVITY BASED FRACTIONAL ORDER ADAPTIVE CONTROL OF DEPTH OF ANESTHESIA
DOI:
https://doi.org/10.52292/j.laar.2019.337Keywords:
Fractional-order adaptation mechanism, Passivity based controller, Depth of anaesthesia, Model reference adaptive controllerAbstract
In this paper, a passivity based model reference adaptive controller with fractional-order adaptation mechanism is utilized for control of depth of anesthesia. The propofol infusion rate is adjusted to reach an appropriate Bispectral Index (BIS). The Pharmacokinetic-Pharmacodynamic (PK-PD) model is employed to model the distribution of propofol in patient body. Since, the PK-PD model parameters depend on physical specifications of patient, employing an adaptive controller to control this system is inevi-table. The utilized controller is a pole placement con-troller in which its polynomial coefficients are ad-justed according to a fractional-order adaptation mechanism. Simulation results on several patients demonstrate the efficiency of the proposed method in the presence of disturbance, noise, and model uncertainties.
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